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Concerns have been expressed regarding the effects of these drugs on pancreatic and thyroid tissue, since animal studies and analyses of drug databases indicate an association of GLP-1 receptor agonists with pancreatitis, pancreatic cancer, and thyroid cancer

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While this slowing often attenuates over time with continued treatment, the effect may persist with long-acting agents and varies between individuals

American Journal of Physiology-Endocrinology and Metabolism, 282(2), E474E482.